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These findings suggest the source of GLP-1 resistance likely occurs farther downstream in the biological pathway

In the SOUL trial (Semaglutide cardiOvascular oUtcomes trial) just published in May 2025, 9650 participants 50 years of age or older who had T2D with a HbA1c of 6.5 to 10.0%, and had known atherosclerotic cardiovascular disease, chronic kidney disease, or both to receive either once-daily oral semaglutide (maximal dose, 14 mg) or placebo, in addition to standard care (5)

No specific side effects are unique to combining semaglutide with oral contraceptives